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- Resources
TLCK
Cat. No. PI-210
Structure:
(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride
Activity:
Serine protease inhibitor
TLCK is a trypsin-like serine protease inhibitor which can block lipopolysaccharide (LPS)- or cytokine-induced activation of nuclear factor κB (NF-κB), which, in turn blocks the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) transcription. TLCK blocks activation of pp70s6k by all mitogens and prevents apoptosis in cell lines by inhibiting caspase processing. TLCK has been used in chymotrypsin purification to prevent binding of trypsins to the affinity support, as a protease inhibitor in tissue and cell homogenization and as a trypsin inhibitor to determine specific protease activity levels.
Kwon et al (1998) Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 47(4) 583 PMID: 9568691
Ménoret (2004) Purification of recombinant and endogenous HSP70s. Methods 32(1) 7 PMID: 14624870
Related areas
All small molecules >
All serine protease modulators >
All immunology research areas >
Technical Data
| Structure | (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride |
| CAS Number | 4272-74-6 |
| Molecular Weight | 369.31 |
| Formula | C14H21ClN2O3S · HCl |
| Sequence | (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Off white powder |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | ≥96% (TLC) |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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